![]() ![]() doi: 10.1038/ncomms11328Ĭhen, I.A., Nowak, M.A.: From prelife to life: how chemical kinetics become evolutionary dynamics. 4, 665–679 (2007)Ĭafferty, B.J., Fialho, D.M., Khanam, J., Krishnamurthy, R., Hud, N.V.: Spontaneous formation and base pairing of plausible prebiotic nucleotides in water. doi: 10.1007/s0023-9īrack, A.: From interstellar amino acids to prebiotic catalytic peptides: a review. doi: 10.1098/rstb.2002.1184īowman, J.C., Hud, N.V., Williams, L.D.: The ribosome challenge to the RNA world. ![]() doi: 10.1016/j.pbiomolbio.2012.09.002īaymann, F., Lebrun, E., Brugna, M., Schoepp-Cothenet, B., Guidici-Oritconi, M.T., Nitschke, W.: The redox protein construction kit: pre-last universal common ancestor evolution of energy-conserving enzymes. doi: 10.1371/journal.pone.0002290īaverstock, K.: Life as physics and chemistry: a system view of biology. BioSystems 95, 227–233 (2009)īaverstock, K., Rönkkö, M.: Epigenetic regulation of the mammalian cell. ![]() doi: 10.1186/s1332-8Īnnila, A., Kuismanen, E.: Natural hierarchy emerges from energy dispersal. doi: 10.1098/rsif.2013.1017Īnnila, A., Kolehmainen, E.: On the divide between animate and inanimate. doi: 10.1007/s1108-0Īnnila, A., Baverstock, K.: Genes without prominence: a reappraisal of the foundations of biology. The results of such debates and investigations might shift current biological paradigms and might also have a momentous significance for modern philosophy in understanding our place in the universe.Īdami, C.: What is complexity? BioEssays 24(12), 1085–1094 (2002)Īdami, C.: Information-theoretic considerations concerning the origin of life. How such reverse translation was achieved at a molecular level is still unclear. Assuming the hypothesis that during the emergence of life evolution had to first involve autocatalytic systems, which only subsequently acquired the capacity of genetic heredity, in the present article we discuss some aspects and causes of the possible emergence of digital, discrete information arising from analogue information realized in the intra- and inter-molecular interactions throughout molecular evolution. Why the translation apparatus evolved, is one of the enduring mysteries of molecular biology. In this sense it is possible to view the ribosome as a digital-to-analogue information converter. The canonical genetic code is one of the most dominant aspects of life on this planet, and thus studying its origin is critical to understanding the evolution of life, including life’s emergence. Within this area of research, the emergence and evolution of the genetic code is supposed to be a critical transition in the evolution of modern organisms. Explaining the emergence of life is perhaps central and the most challenging question in modern science. ![]()
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